滇山楂与山里红总提取物降血脂和促消化作用对比研究

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【中图分类号】R285.5 【文献标志码】A 【文章编号】1007-8517（2025）09-0030-07

DOI： 10.3969/j .issn.1007 -8517.2025. 09. zgmzmjyyzz202509008

Comparative Study on the Lipid-lowering and Digestive Effects of Crataegus scabrifolia （Franch.）Rehd and Crataeguspinnatifida Bge

GONG Lyudong1.2 ZHONG Chengzhi1，² YAN Hong1，² LI Ting1，2 ZI Zhida1，2 WU Desong1，2 GUO Yan1.2 *

1.Yunnan Institute of Materia Medica，Kunming 65O111，China;

2.Yunnan Province Company KeyLaboratory for TCM and Ethnic Drug of New Drug Creation，Kunming 65011，China

Abstract：Objective Tocompare the diferences between Crataegus scabrifolia （Franch.）Rehdand Crataegus pinnatifidaBge. Inreducig bloodlipidsandpromotingdigestion.MethodsAcutehyperlipidemiamodelsofmicewereestablishedbyintraperitoneal injection of 75% egg yolk emulsion，and hyperlipidemia model mice wereestablished by feeding high-fat diet for6 weeks to study andcompare thelipid-loweringefects.Measuringthe propulsionlengthandrateofevans bluetoanalyzeandcomparethedigestive efects.ResultsThetwohyperlipidemia modelmousestudiesshowedasignificantincreasethelevelsofTC，TG，LDL-Cinthe model group compared to the normal group （ P<0.01 ）.However，compared to the model group，Two extracts showed a significant decrease in TG levels in various dosage groups （ P<0.05 or P<0.01 ）.Additionally，the high -dose groups of two extracts exhibited a significant decrease in LDL-C levels （ P<0.05 or P<0.01 ），and there were no significant diffrences in the levels of TC，TG， LDL-C，andHDL-Cbetween Crataegusscabrifolia（Franch.）RehdandCrataeguspinnatfdaBge.Inthedigestionpromotionexperiment，thelow-dosegroupofCrataeguspinnatifidaBge.SignifcantincreasedthepropulsiondistanceandrateofEvasblue（ P （204 <0.01 ）.Conclusion Both Crataegus scabrifolia （Franch.）Rehdand Crataegus pinnatifida Bge.Demonstrated significan lipidloweringeffcts，particularlyinTGndDLClevels，withcomparableeicacy.However，CrtaeguspinnatifidBe.Exibieda notably superior digestive promotion eect compared to Crataegus scabrifolia （Franch.）Rehd.

KeyWords：Crataegus scabrifolia（Franch.）Rehd；Crataegus pinnatifidaBge；Lipid-lowering；DigestivePromotion；Comparative Study

我国有蔷薇科（Rosaceae）山楂属（Cratae-gus）植物共计18种[1]。（剩余8048字）