山桔叶水提物急性毒性试验

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【中图分类号】R285.5 【文献标志码】A 【文章编号】1007-8517（2025）09-0037-04

DOI：10.3969/j. issn.1007-8517.2025.09. zgmzmjyyzz202509009

Acute Toxicity Experiment of Glycosmis parviflorae（Sims）Kurz Water Extract

ZHANG Wentao MA Wenfang HUANG Lizhen* GuangxiUniversity of ChineseMedicine，Nanning53O2OO，China

Abstract：ObjectiveToevaluate theacutetoxicityof Glycosmis paruflorae（Sims）Kurz water extract inmice.Methods The maximum dosage（MAD）wasused inthe acute toxicityexperiment on mice.40 KMmice，2O malesand2O females，were selected andrandomlydividedintotwogroups with2Omiceineachgroup.Thetreat groupwasgiventhewaterextractofGlycosmisparviflore at a volume of 40mL/kg by gavage，and the control group was given equivalent pure water， observed and recorded general condition of mice（toxicreaction，body weightanddeath）within14days.After14days，theserum wastakentodetectthebloodbiochemical indexes，observedthepathologicalchangesinthemainorgansadcaleulatedtheorganindex.Inadition，histopathologicalchangs inthe organ wereanalyzedby hematoxylinandeosin method.ResultsThere werenoobvious toxic symptoms inthetreat group，and nosignificantdiferenceintebdyweights，matologicalandochemicalparametersaswellasistopatologyinorganshncompared with thecontrol group.Conclusion The MAD of water extractof Glycosmis paruflorae（（Sims）Kurz for mice was 218g/kg ， which was 872 times of the recommended dosage for adults （ 60kg ）.Indicatedt hat Glycosmis parviflorae（Sims）Kurz was high safety.

Key Words： Water Extract of Glycosmis parviflorae （Sims） Kurz； Acute Toxicity Experiment；Maximum Does

山桔叶为芸香科山小橘属小花山小橘Glycosmisparviflorae（Sims）Kurz的干燥叶，别名野沙柑、酒饼木、山油甘等，具有止咳、化痰、消积、破瘀消肿的功效，在广西、广东、福建、台湾等均有分布[1-2]。（剩余4829字）