糖皮质激素联合羟氯喹对系统性红斑狼疮的疗效及不良反应的影响

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【摘要】目的：研究系统性红斑狼疮患者在采取糖皮质激素+羟氯喹治疗后的效果。方法：在2016年1月—2021年1月期间，选取100例于我院就诊的系统性红斑狼疮患者为研究对象，随机分为研究组和参照组。研究组采取糖皮质激素+羟氯喹治疗，参照组采取糖皮质激素治疗。结果：研究组治疗有效率高于参照组治疗有效率（P0.05），治疗后两组患者的CD3+、CD4+水平均升高，CD8+水平降低，并且治疗后研究组患者的变化幅度大于参照组（P

【关键词】糖皮质激素；羟氯喹；系统性红斑狼疮

The effect of glucocorticoid + hydroxychloroquine on systemic lupus erythematosus and adverse reactions

JIANG Dan， XIONG Jinhe， JIANG Ting， HE Fang

Suining Central Hospital， Suining， Sichuan 629000， China

【Abstract】Objective： To study the effect of glucocorticoid + hydroxychloroquine in patients with systemic lupus erythematosus. Methods： From January 2016 to January 2021， 100 patients with systemic lupus erythematosus who were treated in our hospital were selected as the research objects and randomly divided into the study group and the reference group. The study group was treated with glucocorticoid + hydroxychloroquine， and the reference group was treated with glucocorticoid. Results： The treatment effective rate of the study group was higher than that of the reference group（P0.05）. After treatment， the levels of CD3+ and CD4+ in the two groups increased， and the level of CD8+ After treatment， the changes of patients in the study group were greater than those in the reference group after treatmen（P

【Key Words】Glucocorticoid； Hydroxychloroquine； Systemic lupus erythematosus

系統性红斑狼疮（SLE）作为一种常见的自身免疫病，因患者免疫系统发生紊乱，体内产生的抗体较多，使得自身的组织造成了一定的破坏，该病具有较为复杂的发病机制，多是由于机体免疫功能障碍导致，引起机体内多种脏器产生自身免疫性炎症，患者临床表现为乏力、疲倦、发热等症状，若病情较为严重，患者还可能出现肾脏、肝脏等脏器衰竭，极大的降低了患者的生活质量[1-2]。（剩余4378字）