口腔潜在恶性病变的临床病理学诊断研究进展

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[中图分类号] R780.2 [文献标志码] A [doi] 10.7518/hxkq.2025.2024427

[Abstract]Asthefieldoforal pathologyhasevolved，thenomenclatureand clasificationoforalmucosaldiseases witha remarkable riskof malignant transformation have undergoneseveral modifications.In 2oo5，the WorldHealth Or

ganization （WHO） introduced the concept of oral potentiallymalignant disorders（OPMDs）asan alternative to theterms fororal precancerouslesionsand precancerous conditions.In the consensusreport by theWHO CollaboratingCenterforOralCancerof2021，OPMDisdefined as“anyoral mucosal abnormalitythatisassociatedwith astatistically increased risk of developing oral cancer.” This definition encompasses a range of conditions， in

cludingoral leukoplakia，oral submucous fibrosis，proliferative verrucous leukoplakia，oralichenplanus，andotherlesions.Inlightoftecomplexetiologyunclearpathogenesis，andcarcinogenesisofOPDs，earlyandprecisediagosis andtreatmentcancontribute tothe secondary prevention oforalcancer.For this reason，thisreview，whichaims toprovidea basis forthe precise clinical diagnosisofOPMDs，was performed.Itsaim wasachieved byreviewing thehistorical evolutionandresearch progressofthe nomenclature，clasification，and histopathological diagnosticcriteriaofOPMDs.

[Keywords]oralpotentiallymalignant disorders；oral leukoplakia；oral submucous fibrosis；proliferative verrucous leukoplakia；oral lichen planus

自1805年首次提出“癌前病变”这一概念以来，它一直指的是那些在长期观察中可能演变为恶性肿瘤的良性疾病。（剩余18300字）