孕晚期阴道微生态失调对新生儿败血症的影响

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Abstract  Objective：To analyze the correlation between vaginal microecology disorder in the third trimester and neonatal septicemia，so as to provide a reference for better prevention and treatment of neonatal septicemia.Methods：A total of 128 mothers of neonates with neonatal septicemia admitted to a tertiary grade A hospital from September 2019 to September 2021 were selected as the case group，and 128 mothers of healthy neonates hospitalized in the same period were randomly selected as the control group.The vaginal microecology of the two groups in the third trimester was detected，the correlation between vaginal microecology disorder in the third trimester and neonatal septicemia was analyzed，and the evaluation value of vaginal microecology index on the risk of neonatal sepsis was tested.Results：The rate of vaginal microecological disorder in the case group（89.1%） was higher than that in the control group（79.7%），the positive rate of candida in case group（7.8%） was higher than that in control group（2.3%），the positive rate of G⁃bacilli（95.3%） was lower than that of the control group（100.0%），and the difference was statistically significant（P<0.05）.Logistic regression analysis results showed that candida positivity in the third trimester was associated with neonatal sepsis（OR=3.721，P=0.045）.Kendall correlation analysis showed that they were positively correlated（r=0.125，P=0.047）.The ROC showed that the AUC of Candida positivity in the third trimester was 0.527 for the assessment of neonatal sepsis.Conclusion：Clinical attention should be paid to vaginal microecological disorder in the third trimester to prevent and reduce the occurrence of neonatal sepsis.

Keywords  third trimester； vaginal microecology； neonates； septicemia； ROC； influencing factors； nursing

摘要  目的：分析孕晚期阴道微生态失调与新生儿败血症的相关性，为更好地防治新生儿败血症提供参考依据。（剩余6939字）