肠道菌群失调及外泌体在帕金森病机制中的研究进展

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【中图分类号】 R742.5 【文献标志码】 A 【文章编号】 1672-7770（2025）02-0226-04

Abstract：Parkinson's disease（PD）isaneurodegenerative disease，and itspathogenesis has not been elucidated so far.Currntly，thegut-brainaxisandexosomesare the two major research hotspots inPD.Thedysbiosis intestinalfloraisinvolvedintheprogressionPDthroughthebrain-gutaxisbyaffctingthebody'sinflammation level，intestinal barrer permeability，and neuroinflammation.Exosomesplayan important roleinPDbyactingas communication messengers to participate in the activation neuroglial cells and the transmission a-syn. By summarizing theefects intestinal flora，exosomesand their synergisticeffectsinPD，wecanprovide some theoretical references for the occurrence and treatment PD.

Key words：parkinson disease；gut-brain axis；gut flora；exosomes

帕金森病（Parkinson'sdisease，PD）是一种慢性神经系统疾病，其主要特征是多巴胺能神经元的丧失，在黑质和纹状体中出现 -突触核蛋白（ -synuclein， -syn）的异常积累。（剩余13488字）