胶质母细胞瘤微环境中巨噬细胞极化影响因素的研究进展

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【中图分类号】 R739.41 【文献标志码】 A 【文章编号】 1672-7770（2025）02-0219-04

Abstract：Glioblastoma（GBM） is the most aggessive form primary intracranial malignancy inadults，and its shortsurvivaldurationis intricatelylinked totheimmunosuppresiveefects mediatedbythetumor microenvironment. The phenotypic transition tumor-assciatedmacrophages（TAMs）ispivotal in establishing immunosuppressive milieuanddriving the progression the disease.This paper presentsa comprehensivereview pertinent literature andemerging research developments to examine the factors governing macrophage polarization within the GBM microenvironment and the underlying mechanisms involved.

Key words：tumor-associated macrophages；glioblastoma；tumor immune microenvironment；macrophage polarization； immunotherapy

胶质母细胞瘤（glioblastoma，GBM）是成人中恶性程度最高的颅内原发性恶性肿瘤，尽管现有的综合治疗手段不断进步，患者中位生存期仍仅为15个月，5年生存率小于 。（剩余9368字）