TGFBR1在肝癌中的表达和对肝癌细胞活性的影响

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中图分类号：R735.7 文献标志码：A 文章编号：1672-1098（2025）02-0100-09

引文格式：，.TGFBR1在肝癌中的表达和对肝癌细胞活性的影响[J].理工大学学报（自然科学版），2025，45（2） ：100-108.

DOI：10.3969/j. issn.1672-1098.2025.02.013

Expression of TGFBR1 in Hepatocellular Carcinoma and Its Impact on Tumor Cell Activity LIU Xinkuang1 ，HUANG Xiaolong

（1.TheFirstHospitalofAnuiUniversityfSienceandTechnology，HuainanAnhui220o，China;2.SchoolofMedicine，Ahi Universityof Science and Technology，Huainan Anhui 232OO1，China）

Abstract： Objective To examine TGFBR1 expression in hepatocellular carcinoma （HCC）and its clinicopathological correlations，as well as validate TGF- β pathway effects on proliferation，migration and invasion.Methods TGFBR1 expression in 25 HCC tisues，from the patients who underwent hepatectomy at the first Anhui University of Technologyafiliated hospital，was assessed via immunohistochemistry.Statistical analyses linked expressionlevels to clinical features. EdU，Transwell，and scratch assays evaluated TGF- β pathway effects. Results TGFBR1 was higher in HCC than that in normal liver tissues （ P<0.05） ），correlating with TNM stage，AFP，ALT，and AST （20 （P<0.05）.TGF-β activation enhanced HCC cell proliferation，migration and invasion. Conclusion TGFBR1 is associated with HCC progression and liver dysfunction，and therefore the research may ofer therapeutic potential for patients with liver cancer.

KeyWords：Transforming growth factorbeta receptorsI（TGFBR1）;hepatocelularcarcinoma;Immunohistochemistry;prolifera tion;migration

肝细胞癌（Hepatocellular carcinoma，HCC）是全球癌症死亡的主要原因之一[1-2]。（剩余10262字）