胃印戒细胞癌的分级与预后存在种族差异：一项SEER数据库和TCGA数据库的研究

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Racial differences in treatment and prognosis of gastric signet ring cell carcinoma： analysisbased on SEER and TCGA databases

FANGShngping2，Jmng²，Eingchn，n²，inning，Gioyu²j SchoolofAsitooitlneolsiclc

Abstract：ObjectiveToanalyzethediferencesintheprognosisofgastricsignetringcellcarcinoma（SRCC）amongdifferent racesusingtheUS Surveilance Epidemiologyand EndResults（SEER）database andTheCancerGenomeAtlas （TCGA） database.Methods Weanalyzedthedataofpatients withgastricSRCCfromtheSEERdatabasefrom200to2020，anddivided thepatientsintocohortsofitesblackssiasoracificnders，AmericanIdians/Alaskaativesacordingtoace. The prognosis and treatmentof the cohorts were evaluated using baseline demographic analysis， Kamplan-Meier survival curve， and nomogram analysis. Results We analyzed the data of a total of 2058 patients， including 8.6% blacks， 72.4% whites， 16.6% Asians or Pacific Islanders， 1.0% American Indians/Alaska Natives， and 1.4% other races. The tumor grade varied among diferentracesnderevalecadalatsoftietsdidgnicantlycossces.irecsineite cohort were the most prominent，and all the differences were statistically significant （P<0.05） . Racial differences were also noted inpatientmanagementandprognosis.ConclusionThereareacialdifferencesintumor gradesandprognosisof gastric SRCC，andthesedifferencesprovideevidenceforoptimzingclinicaldagnosisandtreatmentstrategiesforthismalignancy. Keywords： signet ring cellcarcinoma; racial differences;SEERanalysis; columnar plots;TCGAdatabase

根据世界卫生组织（WHO）的分类，印戒细胞癌（SRCC）被定义为一种黏着性差的癌，主要由肿瘤细胞组成，细胞质粘蛋白突出，细胞核呈新月形，偏心放置[2]。（剩余15841字）