胃肠间质瘤并发胃肠道出血患者的生存状况分析

打开文本图片集

[中图分类号]R574.63［文献标志码］A[文章编号]2097-5716（2025）03-0390-04

DOI： 10.13308/j.issn.2097-5716.2025.03.015

Analysis on survival status of patients with gastrointestinal stromal tumor complicated by gastrointestinalbleedingWU Fengjuan，LIU Na， ZHAO Ya’nan， CHEN Pei（Department of Gastroenterology， Zhengzhou FirstPeople's Hospital， Zhengzhou Henan 450004，China）

[Abstract]ObjectiveTo analyze the survival status of patients with gastrointestinal stromal tumor （GIST） complicated bygastrointestinal bleeding.MethodsThe medical record and postoperative folow-updata of 112 patients with GIST were collcted.All patients were treated with either endoscopic submucosal excavation or laparoscopic surgical intervention. They were divided into a bleeding group （ n=43 ） and a non-bleeding group （ n= 69）according to whetherthe patients were complicated by gastrointestinal bleeding.The pathological characteristics of the tumor，the prognosis of surgical treatment，and thesurvival status of the patients were observed in the two groups.ResultsThere were no statistically significant differences in sex or age between the two groups （both P> 0.05）.In the bleeding group，the proportion of patients with tumors locating outside the stomach was higher，the tumors were larger，therisk grade was higher，and the mitotic figures were more compared to those in the nonbleeding group （all P<0.01 ）. Postoperative immunohistochemical examination results showed that the positive rates of postoperative tissue CD34，CD117，smoth muscle actin，and DOG-1 in the bleeding group were all significantly higher than those in the non-bleeding group （all P<0.05 ）. The recurrence or metastatic rate，and mortality of the patients in the bleeding groupduring folow-up were also both significantly higher than those in the non-bleeding group （the recurrence or metastatic rate ： 37. 21% vs. 15. 94% ，the mortality： 18.60% Us. 4.35% ；both P<0.05 ）. ConclusionPatients with GIST comnlicatedhvoastrointestinal hleeding tend tn have tumorsnredominantlv

distributed inextragastric tissues，which demonstrate accelerated growth speed，higher malignant potential，andare also associated with significantly increased postoperative recurrence or metastasis rate，and mortality. [Key words]gastrointestinal stromal tumor；gastrointestinal bleeding；survival status ； immunohistochemistry

胃肠间质瘤（gastrointestinal stromal tumor，GIST）是胃肠道较为少见的恶性肿瘤，在中老年人群中多发，来源于胃肠间质的Cajal细胞或更加原始的干细胞[1-2]。（剩余4557字）