不同给药途径下替罗非班联合阿托伐他汀对冠心病患者PCI术后抗血小板疗效及血管内皮功能的影响

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[中图分类号]R541.4[文献标志码]A [文章编号] 2097-5716（2025）03-0386-04

DOI： 10.13308/j.issn.2097-5716.2025.03.014

Influence of tirofiban combined with atorvastatin via different administration routes on antiplatelet efficacy and vascular endothelial function in patients with coronary artery disease after percutaneous coronary interventionGUO Donghai’，LIU Xiaomei，PAN Jianjun²（1. Department of Geriatrics，2. Department of Interventional Radiology，the Fourth People's Hospital of Shangqiu，Shangqiu Henan 4760Oo，China）

[Abstract]ObjectiveTo explore the influence of tirofiban combined with atorvastatin via difrent administration routes on the eficacy and vascular endothelial function of patients with coronary heart disease （CHD）after percutaneous coronary intervention（PCI）.MethodsThe clinical data of 13O patients with CHD were retrospectively analyzed，and they were divided into an intravenous administration group（62 cases） and an intracoronary administrationgroup（68 cases）according to the tirofiban administration route.Cardiac function indexes such as LVEF，LVEDD and LVESD，postoperative TIMI blood flow grading，vascular endothelial function indexes including ET-1 and NO，as wellas the occurrence of adverse reactions such as intracranial hemorrhage， exudative hemorrhage and thrombocytopenia were compared between the two groups.ResultsAfter operation， LVEF，LVEDD and LVESD in the intracoronary administration group were significantly beter than those in the intravenous administration group （all P<0.01 ）. TIMI blood flow grading，and vascular endothelial function indexes such as ET-1 andNO were also significantly beter than those in the intravenous administration group（ll P< 0.01）.There was no statistically significant difference in theoccurrence of adverse reactions between the two groups （ P>0.05 ）.ConclusionIntracoronary administration of tirofiban combined with atorvastatin therapy demonstrates superior eficacy in improving antiplatelet effects andvascular endothelial function in CHD patients after PCI.

[Key words]administration route；coronary artery；vein； tirofiban；atorvastatin；percutaneous coronary intervention；coronary heart disease

冠心病的核心致病机制涉及冠状动脉（简称冠脉）壁的粥样硬化病理过程，这一过程致使血管内径变窄乃至闭塞，最终造成心肌血液供应不足，心肌处于缺氧状态，导致心肌细胞受损与死亡[1]。（剩余5435字）