壳聚糖/桃胶止血海绵的制备及其在止血方面的应用潜力

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中图分类号：R318 文献标识码：A

Abstract：This study used CS and PG，with tannic acid as a cross-linking agent，to conduct interpenetrating crossinking reaction and freeze-drying to generate a biodegradable interpenetrating polymer network （IPN），and synthesized a novel CS/PG hemostatic sponge. Cytotoxicity testing using L929 cels demonstrated that the hemostatic sponge synthesized through the crosslinking of CS and PG showed no cytotoxicity on L929 cells. Experimental comparison indicated that when the proportion of PG is 30% ，this material exhibits its best comprehensive performance. The cross-linked CS and PG interpenetrating network structure provided the hemostatic sponge with nice injectability，robust mechanical property，and shape memory performance. Compared with gauze and gelatin hemostatic sponges，our hemostatic sponge has not only better whole blood coagulation function but also beter adhesion and activation capacity of blood cels and platelets. In the liver volume coloboma damage and tail-cutting models of rats，CS/PG3o hemostatic sponge was found to have less bleeding than both gauze and gelatin hemostatic sponge，with a shorter hemostasis time.Among these experiments，the hemostatic effect of CS/PG30 on deep stenotic uncompressible hemorhage was detected through the rat model of deep stenotic uncompresible hemorrhage with hepatic coloboma，which had a better clinical performance.

Key words： peach gum;chitosan;hemostasis

战争、交通事故、自然灾害的发生，容易导致人体大出血。（剩余11664字）