纳米材料在动脉粥样硬化性心血管疾病中的应用进展

中图分类号：R543.3 文献标志码：A DOI：10.11958/20251227

Abstract： Atherosclerotic cardiovascular diseases （ASCVD） are chronic progressive diseases characterized by endothelial dysfunction， and their traditional therapies have limitations. In recent years， nanocarrier systems have demonstrated significant advantages in targeted delivery， enhancing drug safety and efficacy， thereby offering new strategies for precise diagnosis and treatment of ASCVD. Nanomaterials， including polymer nanoparticles， lipid nanoparticles， inorganic nanoparticles and bio-inspired nanoparticles， can effectively intervene key pathological processes of ASCVD. They achieve therapeutic effects by regulating macrophage balance， preserving endothelial cell function， maintaining smooth muscle cell contractile phenotype and modulating platelet activity. This review summarizes the application characteristics and research progress of different types of nanomaterials in the prevention and treatment of ASCVD， and provides insights into the challenges and future prospects of this field.

Key words： atherosclerosis; nanotechnology; drug carriers; drug delivery systems; cardiovascular diseases

动 脉 粥 样 硬 化 性 心 血 管 疾 病（atheroscleroticcardiovascular diseases，ASCVD）是一种以动脉内膜脂质沉积、慢性炎症反应和纤维斑块形成为特征的慢性进行性疾病，是全球范围内患者致死致残的主要病因之一［1］。（剩余15022字）