子宫螺旋动脉超声联合血清CTRP6、sTWEAK对早发型子痫前期的诊断价值

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中图分类号：R714.25 文献标志码：A DOI：10.11958/20250404

Abstract： Objective To explore the diagnostic value of uterine spiral artery ultrasound combined with serum complement C1q tumor necrosis factor related protein 6 （CTRP6） and soluble tumor necrosis factor-like weak inducer of apoptosis （sTWEAK） for early-onset preeclampsia （EOPE）. Methods A total of 104 pregnant women diagnosed with EOPE in early to mid pregnancy were regarded as the EOPE group， and another 104 healthy pregnant women who underwent prenatal examinations were used as the control group. ELISA was applied to measure the expression levels of serum CTRP6 and sTWEAK. Logistic regression analysis was applied to analyze factors influencing the occurrence of EOPE. The diagnostic value of serum CTRP6， sTWEAK and uterine spiral artery ultrasound parameters in EOPE was analyzed by receiver operating characteristic （ROC） curve. Results Compared with the control group， proteinuria quantification， systolic blood pressure， diastolic blood pressure and serum CTRP6 were increased in the EOPE group （ P<0.05 ）， serum sTWEAK level was decreased， and pulsatile index （PI）， resistance index （RI） and peak systolic velocity/end diastolic velocity （S/D） of uterine spiral artery of pregnant women were all increased in the EOPE group （ P<0.05 ）. CTRP6， PI， RI， S/D， systolic blood pressure and diastolic blood pressure were risk factors of EOPE （ P<0.05 ）， and serum level of sTWEAK was the protective factor of EOPE （ P<0.05 ）. The combination of CTRP6， sTWEAK， PI， RI and S/D had the highest AUC in the diagnosis of EOPE， which was better than their individual diagnoses （Z=5.924， 6.583， 5.664， 5.399 and 7.627， P<0.01 ）. Conclusion The combination of uterine spiral artery ultrasound and serum CTRP6 and sTWEAK can better diagnose the occurrence of EOPE.

Key words： eclampsia; ultrasonography， Doppler; cytokine TWEAK; complement C1q tumor necrosis factor related protein 6; uterine spiral artery ultrasound; early onset preeclampsia

子痫前期（preeclampsia，PE）是妊娠期特有的严 重并发症之一，以高血压、蛋白尿和全身多系统受累为特征，严重威胁母婴健康［1-2］。（剩余11189字）