杞菊地黄丸联合氟米龙滴眼液治疗肝肾阴亏型 干眼症的疗效观察

打开文本图片集

中图分类号：R777.3 文献标志码：A DOI：10.11958/20250411

Abstract： Objective To investigate the efficacy Qiju Dihuang pill combined with fluorometholone eye drops on dry eye disease （DED） due to Yin deficiency liver and kidney and its impact on the ocular surface function patients. Methods Ninety-two patients with DED admitted to our hospital from April 2021 to May 2024 were gathered and assigned into two groups using a random number table method， with 46 patients in each group. The conventional group was treated with fluorometholone eye drops， while the combination group was treated with Qiju Dihuang pills on the basis the conventional group. The efficacy， tear film break up time （TBUT）， length tear infiltration， corneal fluorescein staining （FLS） and ocular surface disease index （OSDI） DED patients were compared between the two groups， and adverse reactions were evaluated. Results After treatment， the length TBUT and tear infiltration were significantly increased in the two groups （ P<0.05） ， OSDI and FLS scores were significantly decreased （ P<0.05 ）， and changes were more significant in the combined group （P<0.05） . There was no significant difference in the total incidence adverse reactions between the two groups （ P> 0.05）. The efficacy the combination group was 91.30% （42/46）， which was higher than that the conventional group， 76.09%（35/46）（P<0.05） . Conclusion The combination Qiju Dihuang pill and flumilone eye drops has good therapeutic effect for patients with DED Yin deficiency liver and kidney.

Key words： xerophthalmia; Qi Ju Di Huang pill; fluorometholone; ocular surface function

随着社会老龄化的加速，与年龄增长密切相关的干眼症（dry eye disease，DED）已成为国际眼科领域的研究热点［1］。（剩余10740字）