超敏C反应蛋白胰岛素C肽联合尿微量白蛋白在糖尿病肾病诊断中的临床意义

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Clinical significance of combined hypersensitive C -reactive protein，insulin， C- peptide and urinary microalbuminuria in the diagnosis of type 2 diabetic nephropathy

ZhouZhaoxia，LiGuangjie DepartmentofaboratoryMedicine，JiyuanSecondPeople'sHospital，Jiyuan459ooo，China

【Abstract】 Objective To analyze and study the clinical significance of high-sensitivity C-reactive protein （hs-CRP），insulin，C-peptide and microalbuminuria in the diagnosis of type 2 diabetic nephropathy.Methods One hundred patients with type2 diabetic nephropathy and eightypatients with type2 diabetes admited to Jiyuan Second People's Hospital from October 2023to August 2O24 were selected，and eighty healthy individuals undergoing routine health examination in the same period were selectedas the healthy control group.All three groups underwent measurement of serum hs-CRP，insulin， C-peptide and urinary microalbumin detection.The detectionresults of the four indicators were among the three groups，andthe diagnostic eficacyof thecombined detection was analyzed.ResultsThe levels of insulin，C-peptide，urinary microalbumin and hs-CRP in the diabetic nephropathy group were （21.10±4.23） mmol/L，（6.65±2.13） ng/ml，（275.15±80.33）mg/L and （6.95±2.31） mg/L，respectively.The levels of insulin， C-peptide，urinary microalbumin and hs-CRP in type 2diabetes group were （10.42 ± 1.20）mmol/L，（1.85±0.27） ng/ml，（16.05±2.15）mg/Land （4.10±1.57）mg/L，respectively. The levels of insulin，C-peptide，urinary microalbumin，and hs-CRP in the healthy control group were （9.35 ± 1.19） mmol/L，（1.34 ± （202 0.25）ng/ml，（15.75±2.14）mg/L，and （2.25±0.53）mg/L，respectively.The resultsof hs-CRP，insulin，C-peptideand urinary microalbumin in the diabetic nephropathy group were higher than those in the other two groups （ P <0.05）. Diagnostic efficacy analysis showed that the AUC（95 %C I）of the combined detection of four indicators was 0.953 （0.893，0.997）.Thecombineddetectionoffourindicatorshas highdiagnosticeficacy，withadagnosticsensitivityof 98.00% and specificity of 94.00% .ConclusionThe patients with type 2 diabetic nephropathy are often accompanied byabnormal serum indicators to varying degrees.Through combined detection of relevantindicators， thediagnostic eficacycanbe improvedandanimportantbasis forclinical diagnosis and treatmentcanbe provided.

【Key words】 Diabetic nephropathies；Diagnosis; C-reactive protein; Insulin; C-peptide； MicroalbuminDOI：10.19522/j.cnki.1671-5098.2025.08.010

糖尿病是一类临床常见、高发的慢性病类型，其中2型糖尿病为主要类型，在糖尿病患者中占 90% 以上。（剩余3912字）