儿童侵袭性肺炎链球菌疾病的流行病学特征及耐药性分析

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Epidemiological characteristicsand drug resistance analysis of invasive streptococcus pneumoniae disease inchildren

CaiKun'，LinJin²，HongLiqin

1Department of Laboratory Medicine，Zhangzhou Third Hospital，Zhangzhou 3630o， China; ²Departmentof

Dermatology，ZhangzhouThirdHospital，Zhangzhou363ooo，Cina

【Abstract】 Objective The epidemiological characteristics and drug resistance of invasive streptococcus pneumoniaedisease in children in Zhangzhou were analyzed to provideareference forrational use of antibiotics and standardized treatment.MethodsA total of 527 children diagnosed with childhood invasive streptococcus pneumoniae from January 2023 to December 2024 were selected as the research subjects.The epidemiological characteristicsof childhood invasive streptococcus pneumoniae disease in children were defined，and the sputumof the children wascolected for isolation，cultureof streptococcus pneumoniae，and antimicrobial susceptibility testing.ResultsAmong the 527children aged 0 to 14 years，those aged 2 to 5 years （57.87 % ）had the highest prevalence of the disease，followed by those aged under 2 years old （26.38% ）and thoseaged6to14 years （ 15.75% ） x2=230.260 P<0.001 ）.Therewere306males （ 58.06% ）and221 females （41.93% ），withamale-to-femaleratioof 1.38：1. The high incidence of invasive streptococcus pneumoniae occurred in winter （32.26% ）and summer （26.19% 0 χ2 =27.454， P<0.001 ）.The most common diagnosis was bronchopneumonia （81.02% ），followedbyacute bronchitis （7.21% ）.Pneumococci show high resistance to erythromycin （98.48% ）andclindamycin （95.83% ），with thelowest resistance rates observed for linezolid（（ ）% ），vancomycin（ ）% ），anddaptivir（ 0% ）.However，theyare highly sensitive to linezolid 100% ），daptivir（ 100% ），andvancomycin（ 100% ），with the lowest sensitivity being to cotrimoxazole （6.83% ），clindamycin（ 3.98% ），and erythromycin （1.52% ）.Conclusion Children under 5 years of age had the highest incidence of invasive pneumococcal disease，which occurred predominantly in winter and summer. Theincidence of maleis higher than that of female，and the diagnosis ismostly bronchopneumonia.Invasive streptococcuspneumococcal bacteriaare highlyresistant toerythromycinand clindamycin，and have thehighest sensitivity to linezolid，dafiputineand vancomycin

【Key words】 Pneumococcal intections；Child；Epidemiologic study characteristics；Drug resistance，bacterial

肺炎链球菌又称肺炎球菌，可引起多种不同临床类型的感染，根据肺炎链球菌分离培养的部位分为非侵袭性肺炎链球菌及侵袭性肺炎链球菌两类，其中侵袭性肺炎链球菌较为常见，该病是指病原侵入无菌部位所引发的疾病，如细菌性脑膜炎、脓毒血症及菌血症等。（剩余6681字）