白茅素联合甲硝唑治疗创伤性口腔溃疡的研究

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中图分类号：R780.2 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.06.009

Abstract：Toinvestigatethetherapeuticeficacyandunderlyingmechanismsofcylindrincombinedwithmetronidazole fortraumaticoralulcers，werandomlyassigned36SDrats todiferentgroups.Aftersuccessulmodeling，theratsreceived respective drugtreatments for7days.Generalconditionsofeach group wereobservedandrecorded.Pathologicalchanges inoral mucosa were examinedviahematoxylin-eosinstaining，whileplasma levelsofIL-1andIL-6weredetectedusingELISA.The resultsshowedthatheratsineachgroupexhibitedsymptomsaftersuccessfulmodeling，suchashunchingandcurling，reduced behaviorsandletargysellasdecreasedppetite.Afterduginterention，tesesmptomsmproved，fooeeaplethe weightofthehigh-dosegroupofcombinedmedicationistheclosestotheblankcontrolgroup.Itwasobservedthat theoralulcer wounds inthehigh-dose groupofcombined medicationshowed thebest efectbytreatment.Theresultofhematoxylin-eosin stainingrevealedpathologicalchangesintheepithelialstructureofthemodelinggroup，while thehigh-dosegroupofcombined medicationshowedthebestrecoveryaftertreatment.Comparedtothecylindringroupandthemetronidazolegroup，theresultsof ELISAindicatedthattheexpressionlevelsofIL-1andIL-6weresignificantlyreduced inboththehighandlow-dosegroupsof combinedmedication（ P<0.001 ）.This study demonstrated that the mixed solution ofcylindrinand metronidazole suppresses the expressionofinflammatorfactorsIL-1andIL-6，whichcontributesamoreexcellnt therapeuticinfluence thansingle-agenton traumaticoral ulcers.Itis expected to provide a beter strategy for theclinical treatment of oral ulcers.

Key words： traumatic oral ulcer; cylindrin; metronidazole solution; combination therapy; inflammatory factor

（ActaLaserBiologySinica，2025，34（6）：551-560）

创伤性口腔溃疡是一种临床常见的口腔黏膜疾病，主要表现为局部疼痛、红肿，表面见黄白色假膜、周围红晕，且具有发病急、疼痛明显、伴发感染等临床特点，情况严重者甚至影响到患者进食和语言交流[1-2]。（剩余15216字）