扫频式光学相干断层扫描在眼科的应用研究进展

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关键词：扫频式光学相干断层扫描成像技术；眼底疾病；脉络膜血管指数;无创成像技术；眼底疾病检查 中图分类号：R774 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.06.001

Abstract： Opticalcoherence tomography（OCT）is anon-invasive imaging technique thatuses visible and near-infrared light to provideetailedcrosectionalimagsofumantissewidelyusedforteexamationoffundusdiseass.CurrtlyC is mainlydividedintotwotypes：time-domainandFourierdomain，withtheFourier-domainfurtherdvidedintospectradomin andswept-sourcetypes.These types ofOCTeach have theirowncharacteristics interms ofimage acquisition methods，scaning speed，axial andlateralresolution，andimagingrange.Swept-source OCT（SS-OCT）oftenusesscaning light sources with wavelengths of 1050nm or 1300nm ，which have strong tissue penetration capabilities.Combined with faster scanning speeds andawidersaningange，itcanclearlydisplaytedepstructuresofthetiaandchoroid，demonstratinguiqueadvantages inthequantitative assessmentof thefundus.Based onrecent research advances，this paper willreviewtheapplicationof SS-OCT inocular diseases，aiming to provideareference forearlydiagnosis，elucidationofpathological mechanisms，and evaluation of therapeutic effects in ophthalmology.

Key words：swept-sourceopticalcoherence tomography;fundus diseases; choroidal vesel volume index; non-invasive imaging technology; fundus disease examination

（ActaLaserBiologySinica，2025，34（6）：481-488）

自1991年光学相干断层扫描（opticalcoherencetomography，OCT）被提出以来，该技术在眼科影像领域取得了显著的成果，特别在2000—2005年间经历了飞速发展，尤其是谱域式OCT（spectral-domainOCT，SD-OCT）的问世，极大地提升了成像速度，实现了活体内的超高分辨率OCT成像，突破了成像分辨率的极限，成为该领域的一个重要里程碑[1-2]随着技术的不断发展，OCT从低分辨率的时域式OCT发展到傅里叶域式OCT，后者根据信号的采样方式分为以二极管连续光源的SD-OCT和以扫频激光为光源的扫频式OCT（swept-sourceOCT，SS-OCT）。（剩余19187字）