乳酸-乳酸化轴调控肿瘤免疫微环境

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中图分类号：R730.23 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.06.005

Abstract：Lactatehaslongbeenregardedasametabolicbyproductofglycolysis.Recentstudies，however，haverevealedits pivotalrole inregulatingthe tumorimmune microenvironment （TIME）.Excesslactateaccumulationdisrupts metabolicbalance， suppresses theactivityofTcellsandNKcels，andinduces thepolarizationofimmunosuppressivecels，therebyreshaping the immunelandscapeofTME.Meanwhile，lactylation，asanovelpost-translationalproteinmodification，mediates thegulation ofepigeneticeventsbymetabolicsignals，promotingtheexpreioofimmue-reatedgenes，schasD-，I-1Agl， andfurtherenhancing immune evasion.Thisreview focuses onthemetabolic-epigeneticcoordinationoflactateandlactylation inTIME，elaboratingonlactateproductionandshutling，immune-cellmetabolicinteractions，andtheclicalpotetialof targetinglactatehomeostasis.Adeeperunderstandingof thelactate-lactylationaxis mayprovidenovelmoleculartargetsand research directions for future tumor immunotherapy.

Key Words： lactate; lactylation; tumor metabolism; immune regulation; therapeutic resistance （ActaLaser BiologySinica，2025，34（6）：515-522）

代谢重编程是肿瘤细胞的核心特征之一，也是驱动肿瘤进展的关键因素[1]。（剩余20430字）