端粒长度检测方法的研究进展

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中图分类号：Q751 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.06.003

Abstract：Telomeresare specialized structures atthe endsofchromosomes，composedofrepetitiveDNA sequences and associatedproteins.Theirprimaryroleistomaintainchromosomalstabilityandintegritybypreventingprogresivelossof chromosome ends and unwanted chromosomalrearrangements. Changes in telomere length are closely linkedtoa varietyof diseases，includingancerging，ndadiovasculasorders.erefre，easuingtelomerelengtholdssigicantiolgical importance.Drivenbytechnologicaldvancesadiversearayofmethodsfortelomere-lengthsessmenthasemerged，foring arich technicallandscape.Eachmethodcaiesdistinctadvantagesand limitations，makingitsuitable forparticularesearch goals andapplicationcontexts.Thisreview summarizescurrent findingsonall major telomere-measurement techniquesand offersrecommendations for future technologicaldevelopment，emphasizing the potentialofintegrating innovativeapproaches to enhancediseasediagnosisandtreatmentstrategies，providingresearchersandclinicians withaguideforselectingoptimal methodsand facilitating the translationof telomere biology into precisediagnosticsandpersonalizedtherapies.

Key words： telomere length; detection methods; celllar senescence; biomarker; accurate diagnosis （ActaLaserBiologySinica，2025，34（6）：496-503）

端粒（telomere）作为真核生物染色体末端的“保护结构”，其长度的改变不仅是细胞衰老进程的“生物学时钟”，更是诸如癌症、心血管疾病等重大疾病的关键分子标志物。（剩余15557字）