基于图像配准和自适应窗口方向衬比的眼底散斑流成像

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中图分类号：R331 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.06.008

Abstract：Inthemonitoring，diagnosis，andclinicalmanagementoffundus diseases，thevisualizationoffundus Vascular structures isrecognzedasofparamount importanceforacuratepathologicalasessment.Laser specklecontrastimaging，a wellestablishednon-invasiveopticalimaging technique，iscapableofachieving vesselvisualizationandreal-timedynamic blood flow monitoring，ascontrast agents are notrequired.However，significantnoiseis inevitablyintroducedbythe conventionalcontrastcalculationmethodthatemploysafixed-sizeslidingwindow.Inthepresentstudylaserspecklecotrast imagesarealignedand fused withvascular structural imagesacquired viaLEDlightilumination.Subsequentto fusion，the compositeimagesaresegmentedintoregionalsubsets，andregion-specificoptimalpixelsareselectedbasedonthevariance criterionto performcontrastcomputation.Withinthe vascular boundaryregion，the geometryand dimensionsof theanalysis windoware dynamicalladjustedtoadapttothelocal vascularmorphology.Theresults indicate that thecontrasthas been enhanced by 67.61% .Moreover，in deeper vascular imaging，theproposed method is found to yield superior noise reduction performanceand enhanced imagequality，thereby providing support forthe diagnosis and management ofoculardiseases.

Keywords： laser speckle contrast imaging; fundus; blood flow; image registration; adaptive window （ActaLaserBiologySinica，2025，34（6）：541-550）

眼底微血管承担着输送营养物质以维持视觉功能的关键任务，其功能紊乱是多种视网膜病变与全身慢性病的重要诱因[]。（剩余14309字）