基于气相色谱的六神系列制剂中人工麝香的特征图谱和含量测定

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中图分类号：R284.2 文献标志码：A 文章编号：1002-4026（2025）06-0042-10

开放科学（资源服务）标志码（OSID）

Characteristic chromatograms and content determination of artificial

musk in Liushen series preparations based on gas chromatography

GUO Lumei1，²，WANG Yingchao1，²， ZHANG Zhenkai1，²，LIU Xingpeng1²， CHEN Feng1，2*

（1.Department of Traditional Chinese Medicine of Guizhou Institute for Food and Drug Control，Guiyang500l8，China; 2.Key Laboratory of Quality Control and Evaluation of Traditional Chinese and Ethnic Medicine of Administration forMarketRegulationofGuizhou Provine，Guiyang55oo18，China）

Abstract：Ascientfic，unfied，andreliablecharacteristicchromatogramsanddeterminethecontentof artificial muskin the Liushen series of preparationswas establishedusing gas chromatography（GC）toaccurately reflect its quaity， providing anexperimentalbasis forsubsequentrevisionsof qualitystandards.The similarityof charactersticchromatograms from39 batchesof Liushen seriespreparationswasanalyzedusingTraditional Chinese Medicine ChromatographicFingerprint SimilarityEvaluation Software（2012version），withsimilaritiesallabove0.995.Liushenpils exhibited 5characterstic peaks，while Liushen capsules showed 4，one of which was identiedas muscone.The content of artificial musk inthree types of preparations was determined，with muscone showing a goodlinear relationship withinthe range of 0.0064～0.6388mg/mL （ R=0.999 ）. The average recovery rates（ relative standard deviation） for pils，capsules， and gel agents were 102.3% （1.0%） ， 97.3% （ 1.5%） ，and 103.1% （ 1.6% ）respectively.The established GC characteristic chromatogramsandcontentdeterminationmethodcancomprehensivelyreflectthequalityofarticial musk in LiuShen series preparations and can be used for quality control of artificial musk in these preparations.

Keywords ： Liushen series preparations；artficial musk；muscone；characteristic chromatograms；gaschromatography contentdetermination

六神丸问世于1864年，起源于苏州雷允上，以治疗咽喉疾病和各类温邪时疫著称[1]，是温病学派的代表药。（剩余7598字）