维生素D对脓毒症心肌损伤幼鼠的保护作用及机制研究

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关键词：维生素D 3（VitD3） ；脓毒症；脓毒症心肌损伤；树突状细胞中图分类号：R459.3 文献标志码：A 文章编号：1001-8751（2025）06-0389-06

Study ontheProtective Effect and Mechanism ofVitamin D3 on Septic Myocardial Injury in Young Rats

XiaWen-wen1，Zhu Li-ran1²， SongHang³，Wang zhen1， CuiWei¹，Liu Hai-peng1 （1 Anhui Provincial Children's Hospital，Anhui Institute of PediatricResearch，Hefei 230051; 2 Institute of Health and Medical Technology， Hefei Institutes ofPhysical Science， Chinese Academy of Sciences，Hefei 230031; 3College ofIntegrated Chineseand Western Medicine，Anhui UniversityofChinese Medicine，Hefei 230012）

Abstract： Vitamin D3 helps control the body's immune system， fend off viral infections， prevent dendritic cell（DC） development and maturation，and lessen heart tissue damage inyoung rats with sepsis，a severe systemic infammatory response syndrome. Objective To analyze and explore the protective effect and mechanism of vitamin D3 on myocardial injury in septic youngrats.MethodEstablishasepsis model，observe the pathological changes inits cardiac tissue，and examine the levels ofanti-inflammatorycytokine IL-10and pro-inflammatory cytokine IL-12. Use flow cytometry to detect the expression levels of surface molecules CD83 and CD86 on dendritic cels （DCs） in rat heart.Immunobloting was used to detect the expression of vitamin Dreceptor （VDR）and nuclear transcription factor kB （NF- ⋅κB ），and one-way ANOVA and t-test were used for statistical analysis.ResultVitamin D3 can improve the morphologyofmyocardial tisse insepsis modelrats，raiseIL-1，lowerIL-12content，decrease theexpresionofcell surface markers CD86 and CD83，and raise VDR and NF- σ⋅κB .Conclusion Vitamin D3 can inhibit the activation of cardiac DCs in septic rats and alleviate the damage to cardiac tissue in young septic rats.

Key words： Vitamin D3 2 （VitD3） ；sepsis； septicemia induced myocardial injury; dendritic cell

脓毒症（Sepsis）是一种严重的可能威胁生命的全身炎症反应综合征，涉及全身感染和炎症反应，以及器官组织损伤等一系列损害。（剩余10730字）