凝固酶阴性葡萄球菌的研究进展
中图分类号：R378；R978.1 文献标志码：A 文章编号：1001-8751（2025）06-0378-11
Research Progress on Coagulase-Negative Staphylococci
LiYang-wei， Duan Bao-sheng（1Department ofClinicalLaboratory，KaifengHospitalofTCM，Kaifeng，Henan 475000; 2 Ordos Clinical Medical College，Inner Mongolia Medical University，Hohhot，Inner Mongolia 010000; 3Department of Clinical Laboratory，Ordos Central Hospital，Hohhot，Inner Mongolia ）
Abstract： Staphylococci are common Gram-positive cocci， divided into two main categories： coagulase-positive staphylococi and coagulase-negative staphylococci. Unlike coagulase-positive staphylococi，coagulase-negative staphylococci have long been consideredto have lowor no pathogenicity.Rarelydo coagulase-negative staphylococci produce infections with clinical symptoms，yet they frequently colonize human skin and mucous membranes. However， with the advancement of medical technology and the emergence of immunocompromised patient populations，coagulase-negative staphylococci have now become common pathogens in hospital-acquired infections. Their pathogenic roleis increasingly recognized in clinical hospital setings，making coagulase-negativestaphylococci a growing global public healthconcerm.The purpose of thisarticle is toreview the epidemiology，pathogenicity，and drug resistance of coagulase-negative staphylococci in order to ofer a theoretical foundation for improved treatment and prevention of infections caused by these bacteria.
Key words： coagulase-negative staphylococci； epidemiology； pathogenicity； drug resistance;antibiotic
凝固酶阴性葡萄球菌（Coagulasenegativestaphylococci，CNS）是葡萄串状排列的革兰阳性球菌，是定植在人和动物体表及与外界相通的腔道中的条件致病菌，能引起人和动物的多种感染[1-2]，由于不能产生血浆凝固酶等物质，过去一直被认为无致病作用，在临床样本中也只是作为污染物出现[3-4]，同时其较弱的毒力作用未引起人们重视，随着各种侵入性操作、免疫抑制剂和广谱抗生素的广泛应用，CNS引起的感染日益增多，研究表明现在CNS已经成为医院感染的重要病原菌[5-]，可在人体免疫力低下或有侵入性操作时引起血液感染、尿路感染、心内膜炎、骨和关节感染等[7]，CNS引起的感染很难彻底治愈，主要是因为CNS复杂的抗生素耐药谱和生物膜形成能力[8]。（剩余26437字）
