挥发性有机物暴露与代谢功能障碍相关脂肪性肝病患病风险存在正向关联

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Abstract：Objective Toassess theasociationbetweenurinarylevelsofvolatileorganiccompoundmetabolites （mVOCs）and risksofmetabolicdysfunction-asociatedsteatoticliverdisease（MASLD）inthegeneraladultpopulation.MethodsBasedon4 cyclesofcross-sectional surveysfromthe201-018National HealthandNutritionExamination Survey （NHANES）， generalizedlinearmodelswereemployedtoevaluatetheassociationsbetweenindividualmVOCexposuresandtheriskof MASLD.A two-stage Least Absolute Shrinkage and Selection Operator-Weighted Quantile Sum （LASSO-WQS）regression model wasconstructed toinvestigatetherelationshipbetweenmixed mVOCs exposuresand MASLDrisk，andtherelative contributionsoftheindividualcompoundswerequantitativelyanalyzed.ResultsThesingle-exposureanalysisrevealed significantpositiveasoiationsof-aminothiazoline-4carboxylicacid（CA），N-acety-S-2-arboxyethyl）-cyteine （CEMA），and N-acetyl-5-（3，4-dihydroxybutyl）-L-cysteine （DHBMA）with MASLDrisk after adjusting forconfounders.Inthe two-stage mixed-exposure analysis，the first-stage LASSOregressionidentified6mVOCs with stronger association with MASLD risk.The second-stage WQS regression demonstrated a statisticallysignificant positive asociation betweenmixed mVOCs exposures and MASLD risk （OR=1.306， 95% CI： 1.132-1.507; P<0.001 ），withCEMA contributing the highest weight （36%） .ConclusionThestudyrevealsasignificantpositiveassociationbetweenurinary levelsofmVOCsmixturesand MASLDrisk，suggesting potential hepatotoxic efects ofVOC （especially CEMA）exposures， whichurges future mechanistic studies of VOC mixture-related health impactsand listing of CEMA for health risk control.

Keywords：metabolicdysfunction-asociatedsteatoticliverdisease;volatileorganiccompounds;mixedexposure;weighted quantile sum regression

肝脏是机体新陈代谢及维持稳态的重要器官，也是抵御内源性和外源性毒素的关键屏障[1。（剩余16412字）