糖尿病胫前色素斑的病理改变揭示血管-免疫异常

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Abstract：ObjectiveToexplorepathologicalandimmunecellinfiltrationcharacteristicsofpigmentedpretibialpatchesin diabeticpatients.MethodsForty-twodiabeticpatientsundergoingthighamputationatTianjinMedicalUniversityChuHsienIMemorialHospitalwereenroled.Beforetheoperation，thepretibialskinofthepatientswereexaminedandsampledforHE andMasonstaining.Thethicknessoftheepidermisandthedensityofbloodvesselsinthedermis werecomparedbetween patientswithand without pigmented pretibial patches.Theexpressionsof VEGFAandVEGFR2 intheskintisues were detected using Western blotting， and CD4+ and CD8+ cellsand the CD4/CD8 ratio were analyzed with immunohistochemical staining. Results Comparedwiththepatients without pigmented pretibialpatches，the patients with pigmented pretibial patchesshowedobviousthickeningof theepidermal spinouslayer，iregulardownwardextensionof theepidermal projectins，prkeratosis，elainpoitioninbsalar，iceasdapilriesinteisndloalidelldefinedinflammatorycellinfiltrationaroundthebloodvessels.Inpigmentedpretibialpatchesgroup，Massnstaining revealedirregulararrangement，thickeningandhyalinedegenerationofcolagenfibers，significantlyincreasedepidermal thicknessandbloodvessel densityin thedermis，increased CD4+ cells and the CD4/CD8 ratio，and reduced CD8* cells. ConclusionThepigmented pretibialpatchesindiabeticpatientsshowobviouspathologicalchanges possiblyduetovascular and immune abnormalities.

Keywords： pigmented pretibialpatches;diabeticdermopathy;diabeticcomplications;vascular-immuneabnormalities

糖尿病腔前色素斑（PPP）也称为糖尿病皮肤病（DD），是糖尿病患者最常见的皮肤症状[12]。（剩余12167字）