降脂祛斑方多成分协同调控炎症-代谢网络改善2型糖尿病合并高脂血症：网络药理学与临床验证

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Abstract：ObjectiveToexplorethe therapeutic mechanismofJiangzhi Quban Recipe （JZQBR）for type2diabetes melitus （T2DM）complicated withhyperlipidemia and validateitsclinical eficacyand safety.Methods Theactivecomponentsand disease targetsof JZQBR were screeed using TCMSPandGeneCards databases，followed byprotein-protein interaction analysis and GO and KEGG enrichment analyses. In the animal experiments， ApoE-I- mice were randomized into blank control， model，simvastatintreatmentndlow-andigdoseJQBRgroups.Inelatter4groups，themicewerefedaighatdiet for24weekswithcorrespondingtreatmentsfromWeeks9to24.Thechanges inbodyweight，blood glucose，lipids，liver pathologyandifmatoryoiepiosofeiceeeaed.Iicalsdy7ptsith hyperlipidemia wererandomized equallintocontrol group for treatmentwithmetforminplusempagliflozin and JZQBR group withadditional JZQBRfor12consecutive weeks.Results Network pharmacologyidentified 65potential targets，with quercetineoldolieotdI-6，I-1β， α asthekeytargets.Thetargetswere enrichedmainly in the pathways involving inflammatory responses and diabetic complications. In the ApoE-1 mouse models， JZQBR treatment dose-dependentlyimproved bodyweight，blood glucose，and blood lipid profiles，andhigh-dose JZQBR producedastrongerefectthansimvastatinforimproving hepaticsteatosisandsignificantlyreduced inflammatorycytokine levels.Intheclinical tal，29patients inJZQBRgroupand31inthecontrol groupcompletedthetrial.The patientsinJZQBR groupshowedsignificantimprovementsinbodyweight，FG，G，Hblc，andliverenymeswithignificantlylowersing blood glucoselevel thanthecontrol group.The total effectiverates were comparable betweenthetwo groups.Conclusion JZQBRimproves T2DMcomplicated withhyperlipidemiaposiblybymult-argetregulationof theinflammation-metabolism network.

Keywords： Jiangzhi Qubanrecipe;type2diabetes melitus;hyperlipidemia;network pharmacolog

2型糖尿病（T2DM）与高脂血症共病现象在临床实践中极为常见，我国T2DM患者中高脂血症患病率高达42%[1] 。（剩余16956字）