超级电休克在难治性抑郁中应用的临床研究：一项回顾性研究

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Abstract：ObjectiveToevaluatetheeficacyandsafetyofsuperelectroconvulsivetherapy（ECT）fortreatment-resistant depression （TRD）.Methods Thiscohort study was conductedamong292 patients withTRD，whoreceived super ECTfrom December，2024toJune，225.Eighty-eightof thepatientsreceivedoneelectricalstimulationineachsuperECTprocedure （E1 group），89 had2electricalstimulations （E2 group），and39ad3electrical stimulations （E3group）.Thecorrelationbetween depresion，anxietyandsleepqualityatbaselinewasanalyzed.Thepatientswereevaluatedusing17-itemsHamilton Depression Scale （HAMD-17）at1，3，and6months afterthefirstsuperECTsession，andthetreatmentremisionrateand responserate were compared among the3 groups.The numberof sessions and incidencesof adverse events within6 months werecompared，andtheEEGseizuredurationatthefirstsuperECTsesionwasanalyzed.ResultsSeventy-fourpatients （84.09%） in group E1，76 （76.40% ）ingroupE2，ad （82.05%） ）ingroup E3achieved remission within6monthsafter super ECT.The average number of treatment sessionswas 2.13±1.44 in Group E1， 2.23±2.01 in Group E2， and 2.41±2.15 in Group E3 within 6 months.The baseline HAMA，HAMD-17 and PSQI scores were significantly correlated （P<0.001） . The first seizure duration in E1 group was significantly longer than that in E2 and E3 groups （P<0.001） .Therehospitalizationrateswere significantly higher in E2 group than in E1 groupat3 months （P=0.012） and 6months （P=0.026） . The short-termadverseeffects included fever，headache/diziness，generalpainanddrymouth.ConclusionuperECTissafeandeffectivefortreatmentof TRD patients with a total seizure duration longer than The number of electrical stimulations in each treatment session does not significantly affect the therapeutic efficacy of super ECT.

Keywords：ultra-rapidantidepressant;super electroconvulsive therapy;treatment-resistantdepression

抑郁症已被列为世界第3大疾病负担，每年有大于100万人因抑郁症自杀[1。（剩余15713字）