重度哮喘患儿CT定量参数与临床指标的相关性

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[关键词］哮喘；儿童；体层摄影术，X线计算机；肺功能测试；生物标志物 [中图分类号]R814.42；R562.25 [文献标识码]A DOI：10.3969/j.issn.1672-0512.2026.01.021 ：lation between quantitative CT parameters and clinical indicators in children with severe asthma

YUANXiaoye，QIQian，CHENHaiyan，BIANJunmei

DepartmentofPediatrics，WuhanThirdHospital，Wuhan43oo6O，China.

[Abstract]Objective：ToinvestigatethecorelationbetwenCTquantitativeparametersandclinicalindicatorsinchildren withsevereasthma.Methods：Atotalof40childrenwithsevereasthma（asthmagroup）and4Ochildrenwith funel chest（controlgroup）wereanalyzedretrospectively.TheCTquantitativeparametersandpulmonaryfunctionindicators wereanalyzed.TheCTquantitative parameters were measured，suchastotal lung volume（TLV），mean lung density（MLD）， airtrappingindex（ATI），airwaywallthickness（AWT）andratioofairwaywall thickness tovascularexternal diameter（AWT % ）.The pulmonary function indicatorswere colected，such as forced expiratory volume in onesecond（FEV）， forcedvitalcapacity（FVC），maximalmid-expiratoryflowcurve（MMEF），FEV/FVCratio.Thencorelationsbetweenthe CTquantitativeparametersandpulmonaryfunctionindicators，serum IgElevelwereasessed.Results：Therewerestatistical diferences in TLV，ATI，MLD，AWT and AWT% between the asthma group and the control group （all P<0.05 ）.In the asthmagroup，therewerestatisticallysignificantdferencesinATI，MLD，FVCandFEVbetweenchildrenwithandwithouta history of hospitalization（all P<0.05 ）.AWT% wasnegativelycorrelatedwith FVC（ r= -0.933， P =0.001），FEV（ r=-0.841，P= 0.001）and MMEF（ r= -0.608，P=O.007）. Conclusions： The quantitative parameters of chest CT，including ATI，AWT and AWT%，elevatesignficantlyinchildrenwithsevereasthma，andwhichiscloselyrelatedtolungfunctionandahistoryof asthma-related hospitalization.

[Key words] Asthma;Child;Tomography，X-ray computed;Lung function test;Biomarker

哮喘是常见的青少年慢性呼吸系统疾病，吸入或口服皮质类固醇效果明确，但约 5% 重度哮喘患者对皮质类固醇治疗无应答[1-3]。（剩余6650字）