基于ReHo的经皮耳穴迷走神经刺激治疗轻度认知障碍的疗效机制研究

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[关键词]轻度认知障碍；经皮耳穴迷走神经刺激；功能磁共振成像；疗效机制 [中图分类号]R445.2；R245.323 [文献标识码］A DOI：10.3969/j.issn.1672-0512.2026.01.005

Siuuyonine tnerapeuuc eiicacy anu mecnansmol transcutaneous auricuiar vagus nerve sumuiauon Dasedon neno formild cognitive impairment

GUOChunlei’，XU Tianjiao’，ZHANG Lei’，CAO Jiudongl，YAN Hua²，YANG Ge2 ，FANG Jiliang1

'Departentofdiologuang'aenHospialfinaAcadeofneseedicalSiencesBeijingoChinaet of Geriatrics，Guang'anmen Hospital of China Academy of Chinese Medical Sciences，Beijing lOoo53，China.

[Abstract]Objective：Toexplorethetherapeuticmechanismoftranscutaneousauricularvagusnervestimulation（taVNS）in thetreatmentofmildcognitiveimpairment（MCI）basedonresting-statefMRI.Methods：FortyMCIpatientswereincluded andrandomly dividedintothetaVNSgroupandthesham-taVNSgroup，with2Ocasesineach group.Bothgroupsreceived 24 weeksof taVNSorsham-taVNStreatment，respectively.Clinical scalescoresandfMRIdata were collctedbeforeandafter treatmentforbothgroups.Thediferencevaluesinclinicalscalescoresbeforeandaftertreatmentbetweenthetwogroups werecompared.Thebrainregionswithsignificantdiferences inregional homogeneity（ReHo）valuesaftertaVNS were comparedbetweenthetwogroups.Pearsoncorelationanalysiswasperformed between theReHodiferencevaluesandscores diferencevaluesinthetaVNSgroup.Results：After24weeksof treatment，theimprovementofMoCA-BscoreinthetaVNS group was better than that in the sham-taVNS group（t =-2.618，P=0.009 ）.Compared with the sham-taVNS group，the taVNS groupproducedsignificantReHodecreasesintherightanteriorcingulatecortex（ACC）andleftinferiorfrontalgyrus，and significant ReHo increases in the bilateral cunei and leftlingual gyrus（GRF-corrcted，voxel P <0.01，cluster P <0.05）.In thetaVNSgroup，theReHodiferencvalueoftherightACCbeforeandaftertaVNSwassignificantlypositivelycorrelated with the MoCA-B score difference value （ r=0.498，P=0.025 ），and the ReHo difference value of the left cuneus was negatively correlated with the MoCA-B score difference value（ r=-0.510 ，P=0.022）.Conclusion：TaVNS can improve the cognitive symptomsofMCIpatientsbyregulating theimportantnodesof thecognitivecontrolnetworkandvisual network.

[Keywords]Mildcognitiveimpairment;Transcutaneousauricularvagusnervestimulation;Functionalmagneticresonance

imaging;Therapeutic mechanism

轻度认知障碍（mild cognitive impairment，MCI）是一种介于正常认知和痴呆之间的中间状态，是阿尔茨海默病（Alzheimer'sdisease，AD）的临床前期。（剩余10645字）