射血分数保留的心力衰竭动物模型的现状与展望

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Current Status and Future Prospects of Heart Failure with Preserved Ejection Fraction Animal Models

SONG Junyan 1 ，GENG Zixuan1，ZHOU Jiawe 2 ，LIU Yiru1 ，LI Yang³

（1.GraduateSchool，Heilongjiang Universityof ChineseMedicine，Harbin15o040，Heilongjiang，China；2.TheFirst HospitalofQiqihar，Qiqihar61o，Heilongjiang，China；3.TheFirstAffliatedHospital，Heilongjiang Universityof Chinese Medicine，Harbin 15oo40，Heilongjiang，China）

【Abstract】Heartfailurewithpreservedjectionfraction（pEF）ischaracterizedbyomplexpathogenesisigheterogenitynd lackofefectivetrapeticstrateiesuentlycesiatinglablelicalnalodelstoucidateitschsmsndevauate interventions.WhileeistingliteraturehasreporedvarousrodentandlargeanimalmodelstatcanrecapitulatesomekeyHFpEFphotypes throughdiversestrategies，treemajorliatiospersist：（1）Existingodelslacksiulationsofcommoncomorbiditssuchasatrial fibilltionndalealsedeeprted;odelvatioselelyoasodtholicalndcal indicatorsdlcvialst;colaliteveslckadaddolstreooldp developingcomorbiditymodels，enancinggenderbalance，optimizingpharmacologicalinterventionprotocols，andintegratingmoder technologies to provide guidance for model selection in HFpEF preclinical research.

【Keywords】 Heart failure with preserved ejection fraction;Diastolic dysfunction;Animal model

射血分数保留的心力衰竭（heartfailurewithpreservedejectionfraction，HFpEF），约占全部心力衰竭病例的 50% ，以呼吸困难、运动耐力下降和心脏充盈障碍为主要表现，但左室射血分数正常[1-]。（剩余6444字）