抗氧化纳米材料治疗心肌缺血再灌注损伤的研究进展

Antioxidant Nanomaterials for Myocardial Ischemia-Reperfusion Injury

XU Min，LIU Hong，XIONG Feng

（DepartmentofCardiovascularUltrasound，TheAfliatedHospitalofSouthwest Jiaotong University，TheThirdPeople's

Hospital of Chengdu，Chengdu 610031，Sichuan，China）

【Abstract】Percutaneouscoronaryinterventionistheprimaryclinicalaproachfortreatingacutemyocardialinfarction，butthe morbidityandortalityofcuteyoardialinfarctioainhghuringeperfusioxcesiveprouctioofeactiveoxyeneisd cardiomyocyteapoptosisxacebatepr-existingmycadialinjuryandayevnleadtoieversibledamage.Inentyarsanoapis havedemonstratedsifcantadvantagesinanagingyocardialiseia-repefusionijury（M）.Comparedwithonventioaldrug， nanodrugscanefectivelyehacetherapeuticeficacywhileeducingtoxicsideefectsbyimprovingparmacokineticandpharmacodmic properties.Tisevismmareentsarchrogessotioidantomaterialsfortreatmentiingtoovideerecfor developing novel anti-MIRI nanodrugs.

【Keywords】Reactive oxygen species;Myocardial ischemia-reperfusion injury;Nanozyme;Nanocarier;Antioxidanttherapy

急性心肌梗死是由冠状动脉粥样硬化斑块破裂所引起的最严重的缺血性心脏病。（剩余14610字）