多组学联合分析在主动脉瓣狭窄研究中的应用与进展

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Application and Progress of Multi-Omics Integration Analysis in Aortic Stenosis Research

WANG Fengxia，LIU Fen，XIE Xiang，MA Yitong （The First Affiliated Hospital of Xinjiang Medical University，Urumqi 83Oo54，Xinjiang，China）

【Abstract】Aorticstenosis（AS）isavalvular hartdiseasewhose pathological mechanisms involvecomplexregulationbymultiple factors，includingeics，etabolis，flamationdetacllaratrixmodelig.loughrdiioalsachadee progressiteliicaldanosisndtreamentofAS，hallengseininitsarlydiagosisndpeisecsifatioreakthogsn multi-omics tchnologiesareevolutioingASmechanismresearchwiththecorebeingtoonectdiferentmoleularlevels（gens/ transcription/proteins/metabolism）andintegratequantitativeanalysisofphenotypicfeaturessuchasradiomicstocnstruct multidimensioaldamicgulatoryapsforsystematialllucidatigtediase’sssec.isrticleevisthurralao ofmulti-mictcholsinAseahpsinotetialofulttegaialsisicovegAatis， identifyingarlkdoveotapiceiallistcal dataintegrationallngsinntulicssarchdutlisfutueseahdsngtopridetoreticalfoudatio and technical support for the precision diagnosis and treatment of AS.

【Keywords】 Aortic stenosis;Genomics;Transcriptomics;Metabolomics;Radiomics

主动脉瓣狭窄（aorticstenosis，AS）是一种常见的心脏瓣膜疾病，其发病率随年龄增长而显著增高[]AS的病理生理机制复杂，涉及炎症反应、钙化、纤维化等多种过程。（剩余15400字）