凝血因子XI抑制剂在心房颤动抗凝治疗中的研究新进展

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Recent Advances in Coagulation Factor XI Inhibitors for Anticoagulation Therapy in Atrial Fibrillation

WANGYushu，CHENGJie，DUXiaoxia（IQVIA Pharmaceutical Technology（Shanghai） Co.，Ltd.，Shanghai 2Ooo32，China）

【Abstract】Atrialfilatonisooffostiskctosfocicsendpatsitralfiltionreeloe anticoagulatioteventoboolsmHoweevetioalntssuhafiditoalicoagntseviable theriskofmajorbeding，litigteirseingskppulatio.oagatofctorX（FX）fuctiosasmpifeiriic coagulationpatha;congenitalFXdeficienctypicallausesolymildledngtendencadisssocatedwitheducedtooticisk. ConsequentlyXsedsactiergetfoeneatticolatapeletiiofXt pathologicalthoosisilegelypresevingsigicalhmostasis.isvsumaresthsilgicalfunctiosofadis relationshiptoombossinndrardovsulardassggtdvasinevelontofXibiodetcal trialfindings，and discusses theprospects forFXIinhibitorasananticoagulation strategyinatrialfibrillation.

【Keywords】Atrial fibrillation; Coagulation factor XI;Coagulation factor M inhibitor;Anticoagulation therapy

心房颤动（房颤）是缺血性脑率中的主要危险因素之一，其全球患病率正逐年上升[1-2]，长期抗凝治疗是预防脑卒中的核心策略。（剩余12123字）