基于生物信息学探讨LTBP-4调控心肌梗死后心肌纤维化的潜在靶点预测

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Prediction of Potential Targets for LTBP-4 in Regulating Myocardial Fibrosis After Myocardial Infarction Based on Bioinformatics

GUO Minqi，CHEN Weichen²，KE Mengmeng1，YI Shuting²，WANG Jinping²，ZHANG Yaohui²，YE Haoxin 1 ， QIN Zihao 1 ， ZHOU Leer¹，LUO Bihui² （1.Guangzhou Medical University，Guangzhou 510182，Guangdong，China；2. Department of Cardiovascular Medicine， The First Afliated Hospital of Guangzhou Medical University，Guangzhou 51Oo30，Guangdong，China）

【Abstract】ObjectiveTo investigate the potential target prediction for latent transforming growth factor- β binding protein-4（LTBP4）inregulatingmyocardalfibosisrmyocadialifarctio（M）MethdsBysreeingdioiforaticalysisofdifetialy expreedprotesinheiftagintsueoficeferyproteislatedtothchnisofyoadialfosisredif toexplorepotentialtherapeutictargets.ThePathayCommonsdatabasewasutilizedtoconsructaninteractionnetworkbetweeLB-4 andotherproteins，andAlphaFold3wasemployedtopredictprotein-proteininteractionstructures.ResultsThroughGOandKEGG analyses，weidentifedO53difrentiallexpresedproteinsmongich-4sowdsigiicantupregulatioandnkedfo fibrosis-relatedprotesWesteblotingultsofidtlevaderesioof-4inboticdo.eiteractiotok ofLTBP-4revealedisgulatooleimodlatingstatuschangesofssociatedproteinsntrasfonggothfactβialing pathway.hepredictiososthatthespecificaminocidsequenesofLBP-4couldbindtotransforinggrowthfact-βanditslatency asociatedpeptide，therebyplayingaroleithefibrosisprocssafterMConclusionAfterMI，teexpresioofLTBP-4significantly increasesinthemyocardium，andregulatingLTBP-4maybecomeaoveltherapeuticstrategyformyocardialfibrosisandrelatedheart diseases.

【Keywords】 Myocardial fibrosis;Latent transforming growth factor- β binding protein-4； Transforming growth factor-β1;Bioinformatics

随着中国人口老龄化加剧，心血管疾病发病率持续攀升，尤其是心肌梗死（myocardial infarction，MI），已成为城乡居民主要死亡原因之一[1]。（剩余9942字）