肠源性尿毒症毒素促动脉粥样硬化机制进展

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Mechanism of Atherosclerosis Induced by Gut-Derived Uremic Toxins

WANG Xinyue 1，2 ，CHENG Ke 1，2 ，WANG Jielian1，YANG Shanshan 1，2 ， WANG Yuxin 1，2 ，GAO Yujun 3 ， XIONG Shihong1 （1.Departmentof Nephrology，Tianyou Hospital Afliated to Wuhan Universityof Science and Technology，Wuhan 430064，Hubei，China；2.Wuhan UniversityofScience and Technology，Wuhan 430064，Hubei，China；3. Departmentof Psychiatry，Wuchang Hospital Afliated to Wuhan Universityof Scienceand Technology，Wuhan43o068，Hubei，China）

【Abstract）Gutderiveduictins（Us）soadiioalisfctorfoathroslerosis，igificatlyotbutetoeatd riskofcardioasaeeteadmoaltdeprtofttalisctosudelgegoalitateaoattsi chronickidneydsease.setoxisuulatesstemicallduetmpidalearancandintestialfloadsbiosisndpotee progressoofatheroslerosistoughultiplemchaisms，hichissociatedwithadverseoutomes.Incentyears，teatholgical signfcanceofGUsasedceasigaetionihedancementandefiementof“gut-ideyis”toysrticlei tosystematicallexploreseveralkeyGUTs，bythoroughlyanalyzingtheirsourcesandmetabolicpathways，summarizingthepathogenic mechanismsofthetoxinsinprotingatherosclerosisandeploingoelrtegiesfortirmoval.Tiseseachskstoprovidea scientificbasisforthepreventionandtreatmentofcardiovascularomplicationsinhonickidneydiseasepatients，andtoexploreew perspectives and approaches in related medical and therapeutic strategies.

【Keywords】 Gut-derived uremic toxin;Chronic kidney disease;Atherosclerosis;Gut-kidneyaxis

慢性肾脏病（chronic kidneydisease，CKD）影响着全球 8%～16% 的人群，并已成为全球十大死因之二[1]。（剩余17434字）