犬尿酸-G蛋白偶联受体35信号通路在代谢性心血管疾病中的研究进展

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Kynurenic Acid-G Protein-Coupled Receptor 35 Signaling Pathway in Metabolic Cardiovascular Diseases

NIU Wenhui，WANGLei

（Departmentof NutritionandFood Hygiene，SchoolofPublicHealth，CapitalMedical University，BeijingKeyLaboratory of Environmental and Aging ，Beijing 100069 ，China）

【Abstract】Metaboliccardiovasculardiseasesareamajor global public halth isue，withtheir incidenceandmortalitycontiuingto rise.Thecoreatogechsmsoelysoatdwitabolicsubans.Kyuriccidtialeabolitofta metabolism，issignificantlyreducedinpatientswithvariousmetaboliccardiovasculardiseaseriskfactorsandplaysaroleindisease progresion.RecentstudieshaveshownthatkynurenicacidactivatesGprotein-coupledreceptor35（GPR35），therebyexertingantiinflammatoryectsimprovingmetabolism，ndlatingadiovasularfuntio.Thisvesystematicallsummaresentdvasin thekyureniccid-igalingathaiabolicadiovaslardiseassingtoprovideatoreticalbasisndoveaer theirdiagnosis，treatment，and targeted interventions.

【Keywords】Kynurenic acid;G protein-coupled receptor35;Cardiovascular disease;Metabolic cardiovascular disease

代谢性心血管疾病是指由代谢紊乱（如肥胖、胰岛素抵抗、血脂异常和高血压）直接介导的心血管病变，其疾病负担随人口老龄化及不良生活方式的流行持续加重，已成为中国居民的主要死亡原因[1-2]。（剩余14135字）