调控性RNA在射血分数保留的心力衰竭中的研究进展

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Regulatory RNA in Heart Failure with Preserved Ejection Fraction

DUAN Junfeng,GUO Meizi

(Department of General Practice,Shenzhen Hospital of Southern Medical University，Shenzhen ,Guangdong，

China)

【Abstract】Heart failure with preserved ejection fraction（HFpEF）accounts for more than 50% of all heart failure cases and represents agrowingglobalhealthchallengethaturgentlyrequiresthedevelopmentofnewterapeuticstrategies.ThepathogeesisofHFEFishighly complexvoeeadtoalschdalosis,asps,ealicio andventricularremodeling.Inecentyears,regulatoryRNA（egRNA）hasemergedasakeyfocusiHFpEFresearch.RegRNAs,rarily includingmicrRNA,longnoncodingRNA,andcicularRNA,playacriticalroleinthecardiovascularsystembyfinelyregulatinggene expresionandaedeeplyinvoledinteosetandprogressonofHFpEF.Thiseviesummarzesteregulatorymechanismsndpotential clinicalapplicationveofgRNAinHpEF.Notably,significanthterogenityexistsinteregRNexpresioprofilsmoHEF patientsosinglgtorslatioaleaksdeauticgstueeahldfcusoteatilcal phenotypeswithmolecularsubtypestofurtherelucidatetheunderlyingmechanismsandpromotetheclinicaltranslationandapplicationof regRNA in the precision diagnosis and treatment of HFpEF.

【 Keywords】 Heart failure with preserved ejection fraction,Regulatory RNA,Non-coding RNA,Myocardial remodeling

射血分数保留的心力衰竭（heartfailurewithpreservedejectionfraction,HFpEF）的发病率和住院率随着人口老龄化而增加，HFpEF在心力衰竭患者中占比 50% 以上，并且住院率和病死率与射血分数降低的心力衰竭（heart failure with reduced ejection fraction,HFrEF)相当[1]。（剩余15753字）