胰岛素抵抗与左心衰竭相关性肺动脉高压的研究进展

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Insulin Resistance and Pulmonary Hypertension Associated with Left Heart Failure

DONG Chao¹ ，DAI Hongyan²

（1.SchoolofClinical Medicine，handong SecondMedical UniversityWeifang261053，Shandong，China；2.Department ofCardiac Health，East HospitalofQingdaoMunicipal Hospital，Qingdao HospitalofRehabilitationUniversityQingdao ，Shandong，China）

【Abstract】Pulmonaryhypertensionasociatedwithleftheartfailure（PH-LHF）isasignificantsubtypeoftype2pulmonary hypertensiontatcaoccurindifeenttysofeartflure，rtularlyeartfurewitpreseedjectiofractio.Asanidepentisk factorforavarietyofcardovasulardiseases，sulinrsistane（I）isoselyelatedtoteounceanddevelopentofuloay hypertension.tudieshavesownthatavarietyofpathologicalchangescausedbyIRsuchasinceasedpulmonaryvasulartensiopid vascularendothelialfuntion，ndpulmoaryascularemodeling，aybeinvoedineourncenddevelopmentofH-Itis article，we mainlyreview theresearch statusof IRandPH-LHF，inorder to find new therapeutic targets forPH-LHF.

【Keywords】Pulmonaryhypertensionassociatedwithlftheartfilure;Isulinresistance;Isulisignalingpathway;Oxidativestrs; Inflammatory reaction

肺动脉高压（pulmonaryhypertension，PH）是由多种病因和发病机制引起的，以肺动脉压升高为特征的病理生理状态，最终会发展为右心衰竭甚至死亡。（剩余12925字）