体育锻炼调控微RNA改善急性心肌梗死后心脏康复机制的研究进展

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Mechanisms of Physical Exercise-Regulated MicroRNA in Improving Cardiac Rehabilitation After Acute Myocardial Infarction

WU Chun 1，2 ，LUO Yumei1，2

（1. Guangdong Medical University，Zhanjiang 524023，Guangdong，China； 2. Shenzhen Longgang District People’ sHospital，Shenzhen 518172，Guangdong，China）

【Abstract】MicroRNA（miRNA）representspromisingdiagnosticandtherapeutictargetsinthepathophysiologyof cardiovascular diseases.Asteladingusefatdwid，cuteyocadialifarctioemoaespatologicalalteratiostatnbeliated throughpysicaleisocolcaliteetiotratessoakerfocuteyadialifrctiois， while physical exercisemodulatesmiRNAsignalingpathways（includingmR-22，miR-1192，miR-146，andmiR-126，amongothrs）to regulateardioyteenepresiocetpoptoticpacitypretogicfueuateosisdod promoteangiogensis.iseviesytsiesolelarmecansstoughchpysicalxeiseeglatediAfacltatsostacte myocardialinfarctioardacepairstablisingteoreicalframeorkforevelopigtargeedterapisdeercise-bdabiliatio Futureinvestigationsshouldfurtherelucidatethemechanismsofresistancetrainingandtranslateexperimentalfindingsintoclinical applications.

【Keywords】 Cardiomyocyte;Acute myocardial infarction;Physical exercise;MicroRNA; Cardiovascular disease

急性心肌梗死（acutemyocardialinfarction，AMI）是全球主要的发病和死亡原因之一[1]。（剩余12423字）