艾滋病合并异时性多原发性恶性肿瘤6例并文献复习

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【中图分类号】R512.91 【文献标识码】A

【Abstract】Objective To analyze the clinical characteristics of AIDS complicated with heterogeneous multiple primary malignant tumors （MPMTs），and to provide clinical accumulation for the diagnosis and treatment of AIDS complicated with malignant tumor and improve prognosis. Methods The clinical features， treatment and prognosis of 6 cases of AIDS complicated with heterogeneous MPMTs were analyzed retrospectively. Results The first primary malignant tumor of the 6 AIDS patients was non-Hodgkin lymphoma （2 cases），skin cancer （2 cases），cervical cancer （1 case） and laryngeal cancer （1 case）， respectively. The median age was 49（43， 58） years old， and the median CD4 cell count was 10o （55， 306） /μL . The second primary tumor was lung cancer（2 cases），colon cancer （2 cases），gastric cancer （1 case），and parotid gland malignancies （1 case），with an average CD4 cell count of （354±177 ）cells μL .The mean interval between the two primary malignancies was （67±53） ）months，and three patients with gastrointestinal malignancies died at the end of follow-up， with a survival time of 3-9 months. Conclusion The AIDS patients with malignant tumors should be followed up regularly for along time and be vigilant about the occurrence of MPMTs. Regular gastroenteroscopy can reduce the risk of malignant tumors of digestive tract and is expected to improve the prognosis.

【Keywords】AIDS; Multiple primary malignant tumors; Heterochronism

多原发性恶性肿瘤（multipleprimarymalignanttumors，MPMTs），是指同一患者发生两种及以上的原发性恶性肿瘤，根据发病时间间隔，MPMTs可分为同时性（6个月内发生）与异时性（间隔超过6个月）l。（剩余8954字）