溶瘤病毒疗法在泌尿系肿瘤中的研究进展

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【中图分类号】R737.1 【文献标识码】A

【Abstract】 Oncolytic virus （OV） therapy is an emerging anti-tumor therapeutic approach in which the virus can selectively replicate and destroy tumor cells without damaging normal cells.The virus stimulates the anti-tumor immunoreactive responses by releasing antigens and activating inflammatory responses in the tumor microenvironment. Despite recent advancements in the treatment of advanced urinary tract tumors， subsequent-line treatment options remain limited，and the disease faces clinical challenges such as high recurrence rates and drug resistance. Therefore，there is an urgent need to develop safer and more effective novel treatment strategies and drugs.This article reviews the latest research progress on OV therapy in the treatment of urinary tract tumors，systematically outlining their application prospects，current challenges，and future development directions.

【Keywords】Oncolytic virus therapy; Oncolytic effect; Immunotherapy; Urological cancers; Prostate cancer; Bladder cancer; Kidney cancer

溶瘤病毒（oncolyticvirus，OV）疗法是一种利用经过基因改造或天然具有肿瘤选择性的病毒，在特异性感染并裂解肿瘤细胞的同时，激发机体抗肿瘤免疫应答的新型治疗策略。（剩余17845字）