中国三省农村地区室内PM_2.5暴露与代谢综合征关系研究

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【中图分类号】R122.7；R589 【文献标识码】A

【Abstract】 Objective To evaluate the association between indoor PM2.5 exposure and metabolic syndrome （MetS）in rural areas of three provinces in China. Methods This cross-sectional study was conducted across 240 villages in three Chinese provinces. Participants aged ≥30 years were randomly selected through gender-and age-stratified sampling ineach village.Sociodemographic characteristics，lifestyle habits，medical history，and residential environment features were colected via standardized questionnaires.The prevalence of MetS was assessed based on blood pressure， waist circumference，and fasting venous blood biochemical indices. Indoor PM2.5 concentrations were assessed using PM2.5 monitoring devices that provided continuous 24-hour monitoring over seven days.Multivariable Logistic regression models were constructed to analyze the relationship between PM2.5 exposure levels and MetS risk，with dose-response relationships explored using restricted cubic spline models.Subgroup analysis and sensitivity analysis were also conducted simultaneously. Results A total of 958 participants were included in the study， with a prevalence of MetS of 54.91% .After adjusting for confounders，participants exposed to the highest levels of PM2.5 exhibited significantly elevated MetS risk compared to the lowest exposure [ OR=1.62 ， 95%CI （1.16，2.26）]. Subgroup analyses revealed heightened susceptibility to high PM2.5 exposure among females [OR =2.28 ， 95%CI （1.39，3.75）]， individuals aged 50～<60 years Δ[OR=2.08 ， 95%C[（1.14，3.80）] ，low level of education [OR .=1.99 ， 95%CI （1.33，3.52）]， low level of income [OR=2.26 95%CI （1.20，4.25）]，exposure to household second-hand smoke ΔOR=1.58 0 95%CI （1.10， 2.27）]， those cooking for 1～2h/d [OR .=1.78 ， 95%CI （1.12，2.82）] and individuals engaged in light physical labor [OR ⇒1.55 ， 95%CI （1.07，2.26）]. Sensitivity analyses confirmed the robustness of these findings. Conclusion Elevated indoor PM2.5 exposure is associated with increased MetS risk in rural China， highlighting the need for targeted interventions to address household air pollution and improve indoor air quality.

【Keywords】Metabolic syndrome; Particulate mater 2.5; Indoor air monitoring; Rural China; Cross sectional study

代谢综合征（metabolicsyndrome，MetS）是以腹部肥胖、空腹血糖升高、甘油三酯水平升高、高密度脂蛋白胆固醇水平降低以及高血压聚集发病为主要表现，严重影响机体健康的临床症候群[]。（剩余21147字）