AIlium覆膜金属输尿管支架置入维持性治疗特发性腹膜后纤维化所致输尿管狭窄的有效性和安全性研究

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【关键词】腹膜后纤维化；输尿管梗阻；输尿管狭窄；Allium覆膜金属输尿管支架【中图分类号】 【文献标识码】A

【Abstract】 Objective To evaluate the safety and efficacy of Allum covered metallic ureteral stent placementas a maintenance therapeutic strategy for ureteral stricture secondary to idiopathic retroperitoneal fibrosis （iRPF）through a multicenter retrospective observational study. Methods A retrospective analysis was conducted on clinical data of patients diagnosed with iRPF-induced ureteral stricture，treated at Peking University People's Hospital， Aerospace Center Hospital，and Beijing Changping DistrictHospital of Integrated Traditional Chinese and Western Medicine between June 2020 and June 2024.Allpatients underwent Allium covered metallic ureteral stent implantation. Regular postoperative follow-ups were performed to assess technical successrates，stent patency rates，renal function （serum creatinine levels），improvement in the degree ofhydronephrosis，and asociated complications.Results In this study，a total of 45 stents were implanted in 27 patients （40 renal units），achieving a technical success rate of 100% . The median follow-up duration was 44 months.At the final follow-up，the median serum creatinine level decreased significantly from 121.8μmol/L preoperatively to 100.0μmol/L 0 ⋅P<0.001 ）. The median renal pelvic width also exhibited a significant reduction from 1.7cm preoperatively to 1.0cm 0 ）.During the follow-up period， the primary complication was stent migration （l case， 3.7% ），which was successfully managed endoscopically. The primary patency rate was （204号 97.5% ，and the secondary patency rate following re-intervention was 100% .Conclusion The implantation of Allium covered metallc ureteral stents constitutes a safe and efective minimally invasive terapeutic modality for managing ureteral stricture caused by iRPF. It significantly improves renal function，relieves obstruction， and demonstrates favorable long-term patency outcomes.Stent migration represents the principal complication; however，its incidence is low and it can be successfully addressed through endoscopic intervention.

【Keywords】Retroperitoneal fibrosis; Ureteral obstruction; Ureteral stricture; Allium covered metallic ureteral stent

特发性腹膜后纤维化（idiopathicretroperitonealfibrosis，iRPF）是一种以腹膜后组织慢性炎症和纤维化为特征的罕见疾病，其形成的纤维斑块常包绕并压迫输尿管，导致肾积水和肾功能损害，是iRPF最常见的严重并发症[1-2]。（剩余7288字）