低密度脂蛋白跨内皮细胞转运机制的研究进展

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中图分类号：R543.5 文献标志码：A DOI：10.11958/20251034

Research progress on the mechanism low-density lipoprotein transendothelial transport ZHAO Shuzhan1，JINDongxia1，2，3，LI Ximing1，23△，HAO Tianxu³，LU Yibei³

1Tanjinianjin3Oo22，2TanjinCardiovscular 3， ， △Corresponding Author E -mail： ljsunlight@126.com

Abstract：The transendothelial transport low-density lipoprotein （LDL） itssubendothelial accumulation representacentral pathogenicmechanism inatherogenesis.Thisprocessinvolvesavariety receptors molecular mechanisms thatwork togethertoregulatethetransportLDLinendothelialcelsitsaccumulationinbloodveselwall. Inaddition toreceptor-mediated transport mechanisms，physiological pathological factorssuchas hormones， inflammatorymediatorsmetabolitesalsoplayanimportantroleinit.Recentstudieshavefurther elucidatedthecritical regulatoryroles thesefactorsinLDLtransendothelialtransport，suggestingthattargetingLDLtranscytosismayrepresent aneffctive strategyforthepreventionearlyatherosclerosis the treatmentrelatedvasculardiseases.Thisreview summarizes recent advances in this field discusses their potential clinical applications.

Words： lipoproteins，LDL; protein transport;atherosclerosis; cytokines;transendotheial transcytosis

动脉粥样硬化（atherosclerosis，AS）是一种慢性进行性大中动脉血管病变，其典型病理特征从早期脂质条纹逐渐进展为纤维斑块及晚期易损斑块。（剩余14351字）