中性粒细胞胞外诱捕网对动脉粥样硬化性心血管病的作用机制及其研究进展

中图分类号：R543.5，R323 文献标志码：A DOI：10.11958/20252054

NETsaggravate the processof disease bypromoting inflammatory response，inducing endothelial dysfunction，promoting thrombosis and other mechanisms.The componentssuch as myeloperoxidase （MPO），neutrophil elastase （NE）and citrullinatedhistone H3（CitH3）releasedbyNETscanactivatetheimmuneinflammatorycascade，directlydamagethe vascularendotheliumand promotethrombosis.Invascular inflammation，theformationofNETs isregulatedbyactin，andthe releasedharmfulmoleculescan induceendothelialcell apoptosisanddrivetheprogressof inflammation throughoxidative stress.The degradationand clearance of NETs dependon the action of enzymes such as deoxyribonuclease I（DNaseI）， anditsregulatory mechansms inatherosclerosisand vascularinflammationremaintobefurtherstudied.Basedontheabove mechanism，NETs-relatedmarkershaveshownthepotentialasnoveldiagnosticandprognosticasssmentbiomarkersfor ASCVD.Thisarticleaims to systematicalyelaborate thecore pathological mechanismof NETsdriving ASCVD through inflammatoryactivation，endothelial injuryandthrombosis，providingatheoreticalbasis for targeted intervention.

KeyWords：atherosclerosis; cardiovascular diseases; extracellular traps; vascular inflammation

动脉粥样硬化性心血管病（atheroscleroticcardiovasculardisease，ASCVD）是全球主要死亡原因之一，由动脉粥样硬化（atherosclerosis，AS）导致的心肌梗死和脑卒中等事件占心脑血管疾病总死亡率的85%[1] 。（剩余16354字）