复合型小细胞肺癌多学科诊疗及MRD探索1例

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中图分类号：R734.2 文献标志码：A DOI:10.11958/20251929

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A case study on multidisciplinary support in comprehensive diagnosis and treatment combined small cell lung cancerand exploration MRD

LIU Chang',MENG Fanlu△,YANG Jing,ZHANG Rongxin,WANG Junping,XIONG Jianhua’,ZHONG Diansheng'

, , , ,, ,oo, △Corresponding Author E -mail: mengfanlul0@6.com

Abstract:Combined small cell lung cancer(C-SCLC) accounts for approximately 0% all SCLC cases,while the propotion C-SCLC mixed with squamous cell carcinoma component comprises less than % . At the pathological level, accuratediagnosis requires todistinguishit from otherlung tumor types,andevenrelyon moleculartesting.This article presentsacase a 67-year-oldpatient initiallydiagnosed with aperipheral lung tumor.Thepatient underwent comprehensivemultidisciplinarymanagement,includingsurgicalresection,postoperativepathologicaldiferentialdiagosis, chemotherapy,thoracicradiotherapy,brainmetastasis,cranialradiotherapydynamicfolow-up imagingchangesafter cranialradiotherapy,andcranialsurgery.Molecularresidual disease(MRD)monitoring was integratedatcritical timeoints during dynamic monitoring to informpersonalized treatment decisions.Theearly MDThas brought the patient'scondition undercontrol,andtheoverallsurvival the patient exceededOmonths.Through theintroduction thediagnosisand treatment process this patient,we aim to fer novel perspectives on clinical decision-making for C-SCLC.

KeyWords: neoplasmsby histologic type; chemoradiotherapy;neoplasm,residual;combinedsmallcellung cancer; brain metastasis;multi-disciplinary treatment

复合型小细胞肺癌（combinedsmallcell lungcancer，C-SCLC)在小细胞肺癌(SCLC)中较少见，因小标本活检的局限性，其病理诊断往往见于手术大标本。（剩余14326字）