北京市中关村地区13105例女性高危型HPV感染及基因分型流行病学分析
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中图分类号：R373.9 文献标志码：A DOI：10.11958/20252016
Epidemiological analysis of high-risk HPV infection and genotype distribution in 13 105 women in Zhongguancun area， Beijing
YANG Yanyan，WANG Ping，YI Xue，PENG Jinzhu，HEYu，ZHANG Wenyu，CHEN Lei，Aziya△ Clinical Laboratory，ZhongguancunHospital，Beijingloo19o，China △Corresponding Author E -mail： yansarliljx@sina.com
Abstract：ObjectiveTo analyze theepidemiological characteristics of human papilomavirus （HPV） infection in womeninthe ZhongguancunareaofBeijing，and toevaluate the infectionrates and genotype distributionbetween different populations and age groups.MethodsAretrospective analysis was conducted on HPV genotyping results of13，105 women who visitedthe gynecologyoutpatient departmentorunderwentroutine health check-upsat Zhongguancun Hospital from March2019 to April2024.High-riskHPVgenotypes（15 types）were detected usingafluorescencePCRassay.Positive cases were classifiedassingle，dual or multiple （≥3）infectionsbasedonthe numberof genotypes.Subjects were stratified into six age groups（≤30，31-40，41-50，51-60，61-70，and ⩾ 71years），and the characteristicsof infectionby type and age group were analyzed. ResultsThe overall HPV positivity rate was 10.78% （1，413/13，105），with a significantly higher rate in the outpatient group than that in the health check-up group （ 16.36% Vs. 6.06% ， P<0.01 ）. The three most prevalent genotypes were HPV52 （ 18.83% ，HPV58 13.85% ）， and HPV16 （11.28% ）. Single infections accounted for 79.19% of cases， dual infections for 15.93% and multiple infections for 4.88% . Age distribution showedaU-shaped pattern，with higher infection rate in women aged ≤3O years （15.06% and 61-70 years （ 13.19% ），and the lowest rate in the ≥71 years （8.09 % ） Notably，women aged ⩽30 years had the highest proportion of multiple infections （31.72 % ）.ConclusionThese findings provideabasis forcervicalcancerscreeningstrategies，HPVvaccinationpromotionandindividualizedpreventionofcervical cancer in this region.
Key words： papillomaviridae；uterine cervical neoplasms;epidemiology;papilomavirus vaccines；genotype;human papillomavirus; Zhongguancun; multiple infections
宫颈癌是全球女性第4位常见恶性肿瘤，死亡率居高不下，严重威胁女性健康[1]。（剩余10680字）
