针刺辅助治疗急性发作性偏头痛疗效与安全性的Meta分析

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AbstractObjective：Toevaluatetheefectivenessandsafetyofacupuncture-assistedforacutemigraineaacksusingMetanalys. Methods：TheChinaNationalKnowledgeInfrastructure（CNKl），WanfangDatabase，VIPDatabase，ChineseBiomedicalLiterature Databasebdsdbfeadtltdodroldae asanAcupuncture-asistedtreatmentforacuteepisodicmigraineweresearchedfromtheestablishmentofthedatabasetoNovember 30，2023.TeualityofteincludediteratureasevaluatedandvaliddatawereextractedMetaanalysisofvariousoutcomeindicators wasconductedusingStata17.0andRevMan5.4softwareResults：Atotalof13randomzedcontrledtrialswereincudedintheMetaanalysis，ivolving1436esearchsubjectsAmongte749caseseceivedAcupunctureasstedtreatmentTeresultsofeetaanalysisshowedthattheexperimentalgroupreceivingacupuncture-asistedtreatmentshowedsignificantlyimprovementintermsof efficacy（ $O _ { Ḋ } ＼mathsf { R } _ { Ḋ } = 2 . 7 1 Ḍ$ ， 95%C1 1.95-3.76， P<0.000 0⋅ 1），VASscore（ MD=-0.71 95%C1 —0.89-—0.53， P<0.000 0 1），and frequencyof headacheattacks（ MD=-1.16 95%C1 —1.73--0.58， P<0.000 0 1）compared to the control group.Therewasno statisticallysignificant difference incalcitonin gene-related peptide（ MD=-6.11 95%C1 —14.79-2.58， P=0.17 ）and5-hydroxytryptamine（ MD=9.95 95%Cl -2.28- 22.18， P=0.11 ）betweentheexperimental groupand the control group.The total incidence of adversereactionsand complications such asdizinesdringthiectioastrotestiactiosuseaandoitingrosissndmatoma（witusof1 respectively， P>0.07 ）intheexperimental group showed no statistically significant difference compared to the control group（ OR=1.04 5 （204号 95%C1 0.68-1.58， P=0.85 ）.Conclusion：Existing evidence indicates that acupuncture-asssted treatment for acute migraine attacks can significantlyimprovetheefectivenessrate，reducetheVASscoreandthefrequencyofheadacheatacks.However，thesafetyof acupuncture-assisted treatment needs to be further evaluated.

Keywordsacutemigraine attack;acupuncture;efficacy;safety;Meta-analysis

偏头痛是一种复杂的发作性神经系统疾病，具有反复出现、终生负担的特点，根据其病程特点和发作强度可分为慢性偏头痛和急性发作性偏头痛1。（剩余9000字）